1GC1
HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | G | ENVELOPE PROTEIN GP120 | polymer | 321 | 35429.2 | 1 | UniProt (P04578) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
2 | C | CD4 | polymer | 185 | 20503.3 | 1 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) In PDB | Homo sapiens (Human) | |
3 | L | ANTIBODY 17B | polymer | 213 | 23368.8 | 1 | Homo sapiens (human) | ||
4 | H | ANTIBODY 17B | polymer | 229 | 24483.5 | 1 | Homo sapiens (human) | ||
5 | A, B, D, E | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 4 | In PDB GlyTouCan (G86851RC) | |||
6 | G | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
7 | water | water | 18.0 | 603 | Chemie (HOH) |
Sequence modifications
G: 83 - 127 (UniProt: P04578)
G: 195 - 297 (UniProt: P04578)
G: 330 - 492 (UniProt: P04578)
C: 1 - 185 (UniProt: P01730)
PDB | External Database | Details |
---|---|---|
Gly 79 | - | expression tag |
Ala 80 | - | expression tag |
Arg 81 | - | expression tag |
Ser 82 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 128 | - | linker |
Ala 129 | - | linker |
Gly 194 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 298 | - | linker |
Ala 299 | - | linker |
Gly 329 | - | linker |
Lys 403 | Glu 403 | conflict |
PDB | External Database | Details |
---|---|---|
Asn 184 | Ser 209 | engineered mutation |
Thr 185 | Ile 210 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 103784.7 | |
Branched | Number of molecules | 4 |
Total formula weight | 1469.4 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1548.5 | |
All* | Total formula weight | 106802.6 |