1FQ9

CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	FIBROBLAST GROWTH FACTOR 2	polymer	132	15110.3	2	UniProt (P09038) Pfam (PF00167)	Homo sapiens (human)	FGF2
2	C, D (C, D)	FIBROBLAST GROWTH FACTOR RECEPTOR 1	polymer	225	25274.8	2	UniProt (P11362) Pfam (PF07679)	Homo sapiens (human)	FGFR1
3	E (E)	4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-beta-L-altropyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose	branched		2309.9	1
4	F (F)	4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose	branched		1732.4	1

Sequence modifications

A, B: 15 - 146 (UniProt: P09038)

PDB	External Database	Details
Ser 69	Cys 78	engineered mutation
Ser 87	Cys 96	engineered mutation

C, D: 141 - 365 (UniProt: P11362)

PDB	External Database	Details
Gln 185	Asn 185	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	80770.3
Branched	Number of molecules	2
	Total formula weight	4042.3
All*	Total formula weight	84812.6

*Water molecules are not included.