1FQ9
CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | FIBROBLAST GROWTH FACTOR 2 | polymer | 132 | 15110.3 | 2 | UniProt (P09038) Pfam (PF00167) In PDB | Homo sapiens (human) | FGF2 |
2 | C, D | FIBROBLAST GROWTH FACTOR RECEPTOR 1 | polymer | 225 | 25274.8 | 2 | UniProt (P11362) Pfam (PF07679) In PDB | Homo sapiens (human) | FGFR1 |
3 | E | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-beta-L-altropyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose | branched | 2309.9 | 1 | ||||
4 | F | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose | branched | 1732.4 | 1 |
Sequence modifications
A, B: 15 - 146 (UniProt: P09038)
C, D: 141 - 365 (UniProt: P11362)
PDB | External Database | Details |
---|---|---|
Ser 69 | Cys 78 | engineered mutation |
Ser 87 | Cys 96 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gln 185 | Asn 185 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 80770.3 | |
Branched | Number of molecules | 2 |
Total formula weight | 4042.3 | |
All* | Total formula weight | 84812.6 |