1FPF
STRUCTURAL ASPECTS OF THE ALLOSTERIC INHIBITION OF FRUCTOSE-1,6-BISPHOSPHATASE BY AMP: THE BINDING OF BOTH THE SUBSTRATE ANALOGUE 2,5-ANHYDRO-D-GLUCITOL-1,6-BISPHOSPHATE AND CATALYTIC METAL IONS MONITORED BY X-RAY CRYSTALLOGRAPHY
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | FRUCTOSE 1,6-BISPHOSPHATASE | polymer | 335 | 36503.0 | 2 | UniProt (P00636) Pfam (PF00316) Pfam (PF18913) | Sus scrofa (pig) | |
| 2 | C, D, G, H (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) PubChem (27854) | |||
| 3 | E, I (A, B) | 2,5-anhydro-1,6-di-O-phosphono-D-glucitol | non-polymer | 324.1 | 2 | Chemie (AHG) | |||
| 4 | F, J (A, B) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (34768) PubChem (83862) PubChem (40467049) PubChem (40469468) PubChem (446048) PubChem (44348067) PubChem (45358029) PubChem (40459109) PubChem (515384) PubChem (46874558) PubChem (638042) PubChem (46875232) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (5316444) PubChem (5742864) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (12163610) PubChem (12358355) PubChem (92144436) PubChem (122197642) PubChem (12358354) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 335 (UniProt: P00636)
| PDB | External Database | Details |
|---|---|---|
| Gln 20 | Glu 20 | conflict |
| Thr 96 | Ser 96 | conflict |
| Asn 199 | Asp 199 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73006.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1562.4 | |
| All* | Total formula weight | 74568.4 |
