1EAQ
The RUNX1 Runt domain at 1.25A resolution: A structural switch and specifically bound chloride ions modulate DNA binding
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RUNT-RELATED TRANSCRIPTION FACTOR 1 | polymer | 140 | 15664.2 | 2 | UniProt (Q03347) Pfam (PF00853) | MUS MUSCULUS (MOUSE) | ACUTE MYELOID LEUKEMIA 1 PROTEIN, ONCOGENE AML-1, CORE-BINDING FACTOR, ALPHA B SUBUNIT, CBF-ALPHA B, POLYOMAVIRUS ENHANCER BINDING PROTEIN 2 ALPHA B SUBUNIT, PEBP2-ALPHA B, PEA2-ALPHA B, SL3-3 ENHANCER FACTOR 1 ALPHA B SUBUNIT, SL3/AKV CORE-BINDING FACTOR ALPHA B SUBUNIT |
| 2 | C, D, E, F (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 3 | G, H (A, B) | water | water | 18.0 | 359 | Chemie (HOH) |
Sequence modifications
A, B: 46 - 185 (UniProt: Q03347)
| PDB | External Database | Details |
|---|---|---|
| Ser 72 | Cys 72 | engineered mutation |
| Ser 81 | Cys 81 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31328.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 141.8 | |
| All* | Total formula weight | 31470.3 |
