1E90

Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT	polymer	961	109952.6	1	UniProt (O02697) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454)	SUS SCROFA (WILD BOAR)	PTDINS-3-KINASE P110, PI3K
2	B (A)	3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE	non-polymer		318.2	1	Chemie (MYC)

Sequence modifications

A: 142 - 142 (PDB: 1E90)
A: 143 - 1102 (UniProt: O02697)

PDB	External Database	Details
Ala 143	Pro 143	expression tag
Ala 505	Arg 505	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	109952.6
Non-Polymers*	Number of molecules	1
	Total formula weight	318.2
All*	Total formula weight	110270.8

*Water molecules are not included.