1DQA
COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG, COA, AND NADP+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | PROTEIN (HMG-COA REDUCTASE) | polymer | 467 | 50021.5 | 4 | UniProt (P04035) Pfam (PF00368) | Homo sapiens (human) | |
| 2 | E, H, K, N (A, B, C, D) | COENZYME A | non-polymer | 767.5 | 4 | Chemie (COA) | |||
| 3 | F, I, M, O (A, B, C, D) | 3-HYDROXY-3-METHYL-GLUTARIC ACID | non-polymer | 162.1 | 4 | Chemie (MAH) | |||
| 4 | G, J, L, P (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 471 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 422 - 888 (UniProt: P04035)
| PDB | External Database | Details |
|---|---|---|
| Ile 485 | Met 485 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 200086.1 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 6692.3 | |
| All* | Total formula weight | 206778.4 |
