1D4S
HIV-1 PROTEASE V82F/I84V DOUBLE MUTANT/TIPRANAVIR COMPLEX
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTEIN (HIV-1 PROTEASE) | polymer | 99 | 10837.8 | 2 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus 1 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE |
| 2 | C (A) | N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE | non-polymer | 602.7 | 1 | Chemie (TPV) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Phe 82 | Val 150 | engineered mutation |
| Val 84 | Ile 152 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21675.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 602.7 | |
| All* | Total formula weight | 22278.2 |
