1D4L
HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 PROTEASE | polymer | 99 | 10765.7 | 2 | UniProt (P03369) Pfam (PF00077) | ||
| 2 | C, D, F (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E (A) | (10S,13S,1'R)-13-[1'-HYDROXY-2'-(N-P-AMINOBENZENESULFONYL-1''-AMINO-3''-METHYLBUTYL)ETHYL]-8,11-DIOXO-10-ISOPROPYL-2-OXA-9,12-DIAZABICYCLO [13.2.2]NONADECA-15,17,18-TRIENE | non-polymer | 616.8 | 1 | Chemie (PI9) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 63 | engineered mutation |
| Ile 33 | Leu 89 | engineered mutation |
| Aba 67 | Cys 123 | engineered mutation |
| Aba 95 | Cys 151 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21531.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 905.0 | |
| All* | Total formula weight | 22436.4 |
