1CWC
IMPROVED BINDING AFFINITY FOR CYCLOPHILIN A BY A CYCLOSPORIN DERIVATIVE SINGLY MODIFIED AT ITS EFFECTOR DOMAIN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A | polymer | 165 | 18036.5 | 1 | UniProt (P05092) Pfam (PF00160) UniProt (by SIFTS) (P62937) In PDB | HOMO SAPIENS (HUMAN) | PPIASE, ROTAMASE, CYCLOPHILIN A |
| 2 | C | CYCLOSPORIN A | polymer | 11 | 1234.7 | 1 | NOR (NOR00033) BIRD (PRD_001108) | TOLYPOCLADIUM INFLATUM | CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE |
| 3 | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
C: 1 - 11 (NOR: NOR00033)
| PDB | External Database | Details |
|---|---|---|
| Mnl 8 | Mle 8 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 19271.2 | |
| All* | Total formula weight | 19271.2 |
