1CQH
HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN REF-1 (RESIDUES 59-71 OF THE P50 SUBUNIT OF NFKB), NMR, MINIMIZED AVERAGE STRUCTURE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | THIOREDOXIN | polymer | 105 | 11592.1 | 1 | UniProt (P10599) Pfam (PF00085) | Homo sapiens (human) | |
| 2 | B (B) | REF-1 PEPTIDE | polymer | 13 | 1404.6 | 1 | UniProt (P27695) |
Sequence modifications
A: 2 - 105 (UniProt: P10599)
| PDB | External Database | Details |
|---|---|---|
| Ala 35 | Cys 34 | engineered mutation |
| Ala 62 | Cys 61 | engineered mutation |
| Ala 69 | Cys 68 | engineered mutation |
| Ala 73 | Cys 72 | engineered mutation |
| Thr 74 | Met 73 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 12996.7 | |
| All* | Total formula weight | 12996.7 |
