1CQG

HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN REF-1 (RESIDUES 59-71 OF THE P50 SUBUNIT OF NFKB), NMR, 31 STRUCTURES

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	THIOREDOXIN	polymer	105	11592.1	1	UniProt (P10599) Pfam (PF00085) In PDB	Homo sapiens (human)
2	B	REF-1 PEPTIDE	polymer	13	1404.6	1	UniProt (P27695) In PDB

Sequence modifications

A: 2 - 105 (UniProt: P10599)

PDB	External Database	Details
Ala 35	Cys 34	engineered mutation
Ala 62	Cys 61	engineered mutation
Ala 69	Cys 68	engineered mutation
Ala 73	Cys 72	engineered mutation
Thr 74	Met 73	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	12996.7
All*	Total formula weight	12996.7

*Water molecules are not included.