1CJT
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MN, AND MG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ADENYLATE CYCLASE, TYPE V | polymer | 217 | 24495.4 | 1 | UniProt (P30803) Pfam (PF00211) | Canis lupus familiaris (dog) | PROTEIN VC1 |
| 2 | B (B) | ADENYLATE CYCLASE, TYPE II | polymer | 212 | 23717.0 | 1 | UniProt (P26769) Pfam (PF00211) | Rattus norvegicus (Norway rat) | PROTEIN IIC2, ATP PYROPHOSPHATE-LYASE, ADENYLYL CYCLASE |
| 3 | C (C) | GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) | polymer | 402 | 46656.4 | 1 | UniProt (P04896) Pfam (PF00503) | Bos taurus (cattle) | ALPHA SUBUNIT OF ADENYLATE CYCLASE-STIMULATING G ALPHA PROTEIN, GS-ALPHA, PROTEIN GSA |
| 4 | D, I (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | E (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) PubChem (27854) | |||
| 6 | F (A) | FORSKOLIN | non-polymer | 410.5 | 1 | Chemie (FOK) PubChem (16757823) PubChem (3413) PubChem (176519959) PubChem (47936) PubChem (44120009) PubChem (44363887) PubChem (46783813) PubChem (69645774) PubChem (73759682) PubChem (6603852) PubChem (6604815) PubChem (6610344) PubChem (337799) PubChem (90751269) PubChem (9844450) PubChem (91213948) PubChem (486148) PubChem (92209816) PubChem (92209817) PubChem (95566308) PubChem (95566309) PubChem (13361560) PubChem (13361561) PubChem (13361564) PubChem (13361565) PubChem (92209815) PubChem (5702265) PubChem (124404343) PubChem (117777632) PubChem (133612037) PubChem (124303810) PubChem (124352399) PubChem (124815399) PubChem (124815400) PubChem (129009935) PubChem (129010250) PubChem (139024465) PubChem (142159939) PubChem (146225314) PubChem (159992414) PubChem (162705519) PubChem (162884402) PubChem (163835172) PubChem (168749335) PubChem (171322913) | |||
| 7 | G (A) | 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE | non-polymer | 475.2 | 1 | Chemie (DAD) | |||
| 8 | H (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) PubChem (4478249) | |||
| 9 | J (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 10 | K (C) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) PubChem (135398675) PubChem (135476260) PubChem (136073095) PubChem (136440011) PubChem (137176535) PubChem (169450542) | |||
| 11 | L, M, N (A, B, C) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A: 364 - 580 (UniProt: P30803)
| PDB | External Database | Details |
|---|---|---|
| Met 476 | Val 476 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 94868.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1759.2 | |
| All* | Total formula weight | 96628.0 |
