1BV7
COUNTERACTING HIV-1 PROTEASE DRUG RESISTANCE: STRUCTURAL ANALYSIS OF MUTANT PROTEASES COMPLEXED WITH XV638 AND SD146, CYCLIC UREA AMIDES WITH BROAD SPECIFICITIES
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTEIN (HIV-1 PROTEASE) | polymer | 99 | 10837.8 | 2 | UniProt (P04585) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | C (A) | [4R-(4ALPHA,5ALPHA,6BETA,7BETA)]-3,3'-[[TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-D IYL] BIS(METHYLENE)]BIS[N-2-THIAZOLYLBENZAMIDE] | non-polymer | 758.9 | 1 | Chemie (XV6) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Phe 82 | Val 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21675.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 758.9 | |
| All* | Total formula weight | 22434.5 |
