1AZS
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | VC1 | polymer | 220 | 25010.8 | 1 | UniProt (P30803) Pfam (PF00211) | Canis lupus familiaris (dog) | |
| 2 | B (B) | IIC2 | polymer | 212 | 23717.0 | 1 | UniProt (P26769) Pfam (PF00211) | Rattus norvegicus (Norway rat) | |
| 3 | C (C) | GS-ALPHA | polymer | 402 | 46712.5 | 1 | UniProt (P04896) Pfam (PF00503) | Bos taurus (cattle) | STIMULATORY G-PROTEIN ALPHA SUBUNIT |
| 4 | D (A) | METHYLPIPERAZINOFORSKOLIN | non-polymer | 550.7 | 1 | Chemie (FKP) | |||
| 5 | E (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F (C) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) | |||
| 7 | G, H, I (A, B, C) | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A: 361 - 575 (UniProt: P30803)
| PDB | External Database | Details |
|---|---|---|
| His 362 | Val 443 | conflict |
| Met 476 | Val 557 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 95440.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1114.3 | |
| All* | Total formula weight | 96554.6 |
