1A8K
CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, D, E | HIV PROTEASE | polymer | 99 | 10804.8 | 4 | UniProt (P03367) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | |
2 | A, E | N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide | non-polymer | 833.1 | 2 | BIRD (PRD_000349) Chemie (0Q4) | |||
3 | water | water | 18.0 | 159 | Chemie (HOH) |
Sequence modifications
A, B, D, E: 1 - 99 (UniProt: P03367)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 75 | engineered mutation |
Ile 33 | Leu 101 | engineered mutation |
Ile 63 | Leu 131 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 43219.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1666.1 | |
All* | Total formula weight | 44885.3 |