1PZL
Crystal structure of HNF4a LBD in complex with the ligand and the coactivator SRC-1 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte nuclear factor 4-alpha | polymer | 237 | 26731.0 | 1 | UniProt (P41235) Pfam (PF00104) | Homo sapiens (human) | HNF-4-alpha, Transcription factor HNF-4, Transcription factor 14 |
| 2 | B (B) | steroid receptor coactivator-1 | polymer | 14 | 1618.9 | 1 | GenBank (1906028) UniProt (by SIFTS) (Q15788) | SRC-1 | |
| 3 | C (A) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 138 | Chemie (HOH) |
Sequence modifications
A: 133 - 369 (UniProt: P41235)
| PDB | External Database | Details |
|---|---|---|
| Leu 137 | Asp 137 | engineered mutation |
| Ala 138 | Ser 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28349.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 228.4 | |
| All* | Total formula weight | 28578.3 |
