14CL
Structure of liver pyruvate kinase in complex with TEPP-46
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Isoform L-type of Pyruvate kinase PKLR | polymer | 447 | 48285.4 | 8 | UniProt (P30613) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase |
| 2 | AA, FA, I, KA, N... (E, F, A, G, B...) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 8 | Chemie (FBP) PubChem (10267) | |||
| 3 | BA, GA, J, LA, O... (E, F, A, G, B...) | OXALATE ION | non-polymer | 88.0 | 8 | Chemie (OXL) PubChem (71081) | |||
| 4 | CA, HA, K, P (E, F, A, B) | 6-(3-aminobenzyl)-4-methyl-2-methylsulfinyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one | non-polymer | 372.5 | 4 | Chemie (07T) PubChem (60156291) | |||
| 5 | DA, IA, L, MA, Q... (E, F, A, G, B...) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) PubChem (888) | |||
| 6 | EA, JA, M, NA, R... (E, F, A, G, B...) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) PubChem (813) | |||
| 7 | SA, TA, UA, VA, WA... (A, B, C, D, E...) | water | water | 18.0 | 1231 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 129 (UniProt: P30613)
A, B, C, D, E, F, G, H: 233 - 545 (UniProt: P30613)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asp 12 | Ser 12 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 130 | - | linker |
| Ser 131 | - | linker |
| Gly 132 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 386283.0 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 5422.2 | |
| All* | Total formula weight | 391705.2 |
