13LJ

Structure of human TRPV3-G568C Olmsted syndrome mutant in the closed state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Isoform 2 of Transient receptor potential cation channel subfamily V member 3,Green fluorescent protein	polymer	1052	120184.1	4	UniProt (Q8NET8) UniProt (P42212)	Homo sapiens (human)
2	AA, BA, CA, DA, E... (C, A, D, B)	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	32	Chemie (POV)
3	FA, N, O, P (C, A)	SODIUM ION	non-polymer		23.0	4	Chemie (NA) PubChem (923)
4	OA, PA, QA, RA (A, B, C, D)	water	water		18.0	149	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 791 (UniProt: Q8NET8)

PDB	External Database	Details
Cys 568	Gly 568	engineered mutation
Leu 792	-	linker
Val 793	-	linker
Pro 794	-	linker
Arg 795	-	linker
Gly 796	-	linker
Ser 797	-	linker
Ala 798	-	linker
Ala 799	-	linker
Ala 800	-	linker
Ala 801	-	linker
Val 802	-	linker

A, B, C, D: 803 - 1039 (UniProt: P42212)

PDB	External Database	Details
Leu 865	Phe 64	conflict
Thr 866	Ser 65	conflict
Lys 1007	Ala 206	conflict
Leu 1032	His 231	conflict
Ser 1040	-	expression tag
Gly 1041	-	expression tag
Leu 1042	-	expression tag
Arg 1043	-	expression tag
Ser 1044	-	expression tag
Trp 1045	-	expression tag
Ser 1046	-	expression tag
His 1047	-	expression tag
Pro 1048	-	expression tag
Gln 1049	-	expression tag
Phe 1050	-	expression tag
Glu 1051	-	expression tag
Lys 1052	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	480736.2
Non-Polymers*	Number of molecules	36
	Total formula weight	24414.4
All*	Total formula weight	505150.6

*Water molecules are not included.