12OY

Single particle cryo-EM structure of human MTCH2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mitochondrial carrier homolog 2,Mitochondrial brown fat uncoupling protein 1	polymer	304	33557.2	1	UniProt (Q9Y6C9) UniProt (P25874)	Homo sapiens (human)	Met-induced mitochondrial protein,UCP 1,Solute carrier family 25 member 7,Thermogenin
2	B (B)	UCP1 Nanobody	polymer	127	13913.5	1		synthetic construct

Sequence modifications

A: 1 - 202 (UniProt: Q9Y6C9)

PDB	External Database	Details
Val 199	Leu 199	engineered mutation
Tyr 200	Ala 200	engineered mutation

A: 203 - 222 (UniProt: P25874)
A: 223 - 304 (UniProt: Q9Y6C9)

PDB	External Database	Details
Ala 227	Thr 226	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47470.7
All*	Total formula weight	47470.7

*Water molecules are not included.