12OB

Crystal Structure of serine/threonine-protein kinase (AEK1) from Trypanosoma cruzi in complex with AMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Putative rac serine-threonine kinase	polymer	361	41729.3	2	UniProt (Q4E2L0) Pfam (PF00069)	Trypanosoma cruzi
2	C, D (A, B)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP) PubChem (6083)

Sequence modifications

A, B: 123 - 474 (UniProt: Q4E2L0)

PDB	External Database	Details
Met 122	-	initiating methionine
Ile 185	Thr 185	engineered mutation
Phe 227	Val 227	engineered mutation
Ser 314	Asn 314	engineered mutation
Leu 475	-	expression tag
Glu 476	-	expression tag
His 477	-	expression tag
His 478	-	expression tag
His 479	-	expression tag
His 480	-	expression tag
His 481	-	expression tag
His 482	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83458.5
Non-Polymers*	Number of molecules	2
	Total formula weight	694.4
All*	Total formula weight	84153.0

*Water molecules are not included.