12KY

Crystal structure of H5 hemagglutinin E190/Q226 from the A/British_Columbia/PHL-2032/2024 (H5N1) with LSTa

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E (E, A, C)	Hemagglutinin HA1	polymer	325	36517.4	3	UniProt (A0A7S5HB03)	Influenza A virus
2	B, D, F (F, B, D)	Hemagglutinin HA2	polymer	171	19826.8	3	UniProt (A0A7S5LHG2)	Influenza A virus
3	G (G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	H, K (H, K)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
5	I (I)	N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		674.6	1	In PDB GlyTouCan (G46776WR)
6	J, L (J, L)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G81315DD)
7	M, N, O, P, Q (E, A, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG) PubChem (24139)
8	R, S, T, U, V... (E, F, A, B, C...)	water	water		18.0	211	Chemie (HOH)

Sequence modifications

E, A, C: 11 - 324 (UniProt: A0A7S5HB03)

PDB	External Database	Details
Ala 7	-	expression tag
Asp 8	-	expression tag
Pro 9	-	expression tag
Gly 10	-	expression tag
Ala 46	Thr 36	conflict

F, B, D: 7 - 174 (UniProt: A0A7S5LHG2)

PDB	External Database	Details
Asp 146	Asn 475	conflict
Ser 175	-	expression tag
Gly 176	-	expression tag
Arg 177	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	169032.6
Branched	Number of molecules	6
	Total formula weight	3769.5
Non-Polymers*	Number of molecules	5
	Total formula weight	1106.0
All*	Total formula weight	173908.1

*Water molecules are not included.