12KF

Crystal structure of H5 hemagglutinin E190/Q226 from the A/British_Columbia/PHL-2032/2024 (H5N1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E (A, C, E)	Hemagglutinin HA1	polymer	325	36517.4	3	UniProt (A0A7S5HB03)	Influenza A virus
2	B, D, F (B, D, F)	Hemagglutinin HA2	polymer	171	19826.8	3	UniProt (A0A7S5LHG2)	Influenza A virus
3	G (G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-3)-1-deoxy-alpha-D-mannopyranose	branched		732.7	1
4	H (H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-3)-1-deoxy-alpha-D-mannopyranose	branched		732.7	1
5	I (I)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-1-deoxy-alpha-D-mannopyranose	branched		570.5	1
6	J (A)	1-deoxy-alpha-D-mannopyranose	non-polymer		164.2	1	Chemie (AH2) PubChem (445184)
7	K, L, M, N, O... (A, C, E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG) PubChem (24139)
8	Q, R, S, T, U... (A, B, C, D, E...)	water	water		18.0	414	Chemie (HOH)

Sequence modifications

A, C, E: 11 - 324 (UniProt: A0A7S5HB03)

PDB	External Database	Details
Ala 7	-	expression tag
Asp 8	-	expression tag
Pro 9	-	expression tag
Gly 10	-	expression tag
Ala 46	Thr 36	conflict

B, D, F: 7 - 174 (UniProt: A0A7S5LHG2)

PDB	External Database	Details
Asp 146	Asn 475	conflict
Ser 175	-	expression tag
Gly 176	-	expression tag
Arg 177	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	169032.6
Branched	Number of molecules	3
	Total formula weight	2035.9
Non-Polymers*	Number of molecules	7
	Total formula weight	1491.4
All*	Total formula weight	172559.9

*Water molecules are not included.