12FJ
Crystal structure of 6-fluoropyrazolo[1,5-a]pyridine derivative bound to KIT
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (AAA) | Mast/stem cell growth factor receptor Kit | polymer | 339 | 38560.6 | 1 | UniProt (P10721) Pfam (PF07714) | Homo sapiens (human) | SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| 2 | B (AAA) | ~{N}-[5-(5-cyclopropyl-4~{H}-1,2,4-triazol-3-yl)-4-fluoranyl-2-methyl-phenyl]-6-fluoranyl-pyrazolo[1,5-a]pyridine-3-carboxamide | non-polymer | 394.4 | 1 | Chemie (A1DJF) |
Sequence modifications
AAA: 544 - 703 (UniProt: P10721)
AAA: 754 - 935 (UniProt: P10721)
| PDB | External Database | Details |
|---|---|---|
| Gly 539 | - | expression tag |
| Pro 540 | - | expression tag |
| Met 541 | - | expression tag |
| Asp 542 | - | expression tag |
| Pro 543 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Thr 704 | - | linker |
| Ser 705 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38560.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 394.4 | |
| All* | Total formula weight | 38955.0 |
