12FG
KRAS G12V in complex with GDP and a macrocyclic inhibitor (Compound 12).
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2B of GTPase KRas | polymer | 171 | 19445.9 | 1 | UniProt (P01116) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 3 | C (A) | (11~{S},15~{R},17~{Z})-8-[[(1~{R},3~{R},6~{S})-2,3-dimethyl-2-azabicyclo[4.2.0]octan-6-yl]methoxy]-23,32-bis(fluoranyl)-15-methyl-18$l^{4}-oxa-3,7,9,11,16-pentazahexacyclo[20.7.1.1^{2,6}.1^{11,15}.0^{5,10}.0^{26,30}]dotriaconta-1(29),2(32),3,5(10),6,8,17,22(30),23,25,27-undecaene-17,28-diol | non-polymer | 672.8 | 1 | Chemie (A1DBZ) | |||
| 4 | D (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 5 | E, F, G, H (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 6 | I (A) | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Val 12 | Gly 12 | engineered mutation |
| Ser 51 | Cys 51 | engineered mutation |
| Leu 80 | Cys 80 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19445.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1524.5 | |
| All* | Total formula weight | 20970.4 |
