12ER

Cryo-EM structure of BCMA in complex with the BCMA-targeted Fab arm of teclistamab and the Fab fragment of an anti-lambda light chain antibody REGN15499

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Heavy chain of the Fab fragment of an anti-lambda light chain antibody REGN15499	polymer	216	23242.0	1		Mus musculus
2	B (B)	Light chain of the Fab fragment of an anti-lambda light chain antibody REGN15499	polymer	214	23588.0	1		Mus musculus
3	C (C)	Tumor necrosis factor receptor superfamily member 17	polymer	82	9219.3	1	UniProt (Q02223) Pfam (PF09257)	Homo sapiens (human)	B-cell maturation protein
4	D (D)	Heavy chain of the BCMA-targeted Fab arm of teclistamab	polymer	221	23411.2	1		Homo sapiens
5	E (E)	Light chain of the BCMA-targeted Fab arm of teclistamab	polymer	214	22654.9	1		Homo sapiens

Sequence modifications

C: 1 - 54 (UniProt: Q02223)

PDB	External Database	Details
Glu 55	-	expression tag
Gln 56	-	expression tag
Lys 57	-	expression tag
Leu 58	-	expression tag
Ile 59	-	expression tag
Ser 60	-	expression tag
Glu 61	-	expression tag
Glu 62	-	expression tag
Asp 63	-	expression tag
Leu 64	-	expression tag
Gly 65	-	expression tag
Gly 66	-	expression tag
Glu 67	-	expression tag
Gln 68	-	expression tag
Lys 69	-	expression tag
Leu 70	-	expression tag
Ile 71	-	expression tag
Ser 72	-	expression tag
Glu 73	-	expression tag
Glu 74	-	expression tag
Asp 75	-	expression tag
Leu 76	-	expression tag
His 77	-	expression tag
His 78	-	expression tag
His 79	-	expression tag
His 80	-	expression tag
His 81	-	expression tag
His 82	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	102115.3
All*	Total formula weight	102115.3

*Water molecules are not included.