12BN
Structural insights into the exosite-mediated activation of Factor IX by Factor XIa using cryoEM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (E, F) | Coagulation factor IX | polymer | 415 | 47158.2 | 2 | UniProt (P00740) | Homo sapiens (human) | Christmas factor,Plasma thromboplastin component,PTC |
| 2 | C, E (A, C) | Coagulation factor XIa heavy chain | polymer | 369 | 41262.1 | 2 | UniProt (P03951) | Homo sapiens (human) | |
| 3 | D, F (B, D) | Coagulation factor XIa light chain | polymer | 236 | 26686.4 | 2 | UniProt (P03951) | Homo sapiens (human) | |
| 4 | G, H, I, J, K... (E, F) | CALCIUM ION | non-polymer | 40.1 | 16 | Chemie (CA) PubChem (271) | |||
| 5 | AA, BA, CA, DA, W... (C, D, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) PubChem (24139) |
Sequence modifications
B, D: 370 - 605 (UniProt: P03951)
| PDB | External Database | Details |
|---|---|---|
| Ala 557 | Ser 575 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 230213.3 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2410.9 | |
| All* | Total formula weight | 232624.3 |
