12AQ
Cryo-EM structure of alpha-synuclein filaments (doublet) from Parkinson's disease with A53T mutation in SNCA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (J) | Alpha-synuclein | polymer | 140 | 14506.1 | 1 | UniProt (P37840) | Homo sapiens (human) | Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor,NACP |
| 2 | B (K) | island B | polymer | 9 | 784.0 | 1 | Homo sapiens (human) | ||
| 3 | C, D (J, K) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
J: 1 - 140 (UniProt: P37840)
| PDB | External Database | Details |
|---|---|---|
| Thr 53 | Ala 53 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 15290.1 | |
| All* | Total formula weight | 15290.1 |
