12AI
Structure of mammalian Type 2 Inositol 1,4,5-trisphosphate receptor (IP3R2) in the presence of IP3/Ca2+/ATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 | polymer | 2701 | 307854.7 | 4 | UniProt (Q9Z329) | Mus musculus (house mouse) | IP3 receptor isoform 2,IP3R 2,InsP3R2,Inositol 1,4,5-trisphosphate receptor type 2,5-trisphosphate type V receptor,Type 2 inositol 1,5-trisphosphate receptor,Type 2 InsP3 receptor |
| 2 | E, J, O, T (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, K, P, U (A, B, C, D) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 4 | G, L, Q, V (A, B, C, D) | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE | non-polymer | 420.1 | 4 | Chemie (I3P) | |||
| 5 | H, M, R, W (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 6 | I, N, S, X (A, B, C, D) | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL | non-polymer | 767.1 | 4 | Chemie (PLX) |
Sequence modifications
A, B, C, D: 1 - 2701 (UniProt: Q9Z329)
| PDB | External Database | Details |
|---|---|---|
| Asp 1004 | Asn 1004 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 1231418.9 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 7199.6 | |
| All* | Total formula weight | 1238618.5 |
