11TH

Structure of human CCR4 in complex with FLX475

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	Anti-BRIL Fab heavy chain	polymer	229	24321.1	1		Homo sapiens
2	B (L)	Anti-BRIL Fab light chain	polymer	214	23353.9	1		Homo sapiens
3	C (R)	C-C chemokine receptor type 4,Soluble cytochrome b562	polymer	475	54284.0	1	UniProt (P51679) UniProt (P0ABE7)	Homo sapiens (human)	C-C CKR-4,CC-CKR-4,CCR-4,CCR4,K5-5,Cytochrome b-562
4	D (R)	2-[(3R)-3-(1-{1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl}azetidin-3-yl)piperidin-1-yl]ethan-1-ol	non-polymer		543.4	1	Chemie (A1DAP)

Sequence modifications

R: 1 - 231 (UniProt: P51679)
R: 237 - 341 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 243	Met 29	conflict
Ile 338	His 124	conflict
Leu 342	-	linker
Glu 343	-	linker
Arg 344	-	linker
Ala 345	-	linker
Arg 346	-	linker
Ser 347	-	linker
Thr 348	-	linker
Leu 349	-	linker
Asn 350	-	linker
Glu 351	-	linker

R: 352 - 475 (UniProt: P51679)

PDB	External Database	Details
Ala 232	-	linker
Arg 233	-	linker
Arg 234	-	linker
Gln 235	-	linker
Leu 236	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	101959.0
Non-Polymers*	Number of molecules	1
	Total formula weight	543.4
All*	Total formula weight	102502.4

*Water molecules are not included.