11SJ
Covalent stabilizer compound 15B for the interaction between 14-3-3 sigma and Estrogen receptor-alpha peptide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | 14-3-3 protein sigma | polymer | 253 | 28132.4 | 2 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (human) | Epithelial cell marker protein 1,Stratifin |
| 2 | C, D (X, Y) | Estrogen receptor | polymer | 15 | 1726.8 | 2 | UniProt (P03372) Pfam (PF12743) | Homo sapiens | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 3 | E, F (A, C) | (2S)-2-(1-acetylpiperidin-4-yl)-1-[(3R,5S)-4-(chloroacetyl)-3,5-dimethylpiperazin-1-yl]-2-(4-chlorophenyl)ethan-1-one | non-polymer | 468.4 | 2 | Chemie (A1DAJ) | |||
| 4 | G, H, I, J (A, C, X, Y) | water | water | 18.0 | 308 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 248 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 59718.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 936.8 | |
| All* | Total formula weight | 60655.2 |
