11PH
Cryo-EM structure of CAS:Ran-GTP:importin alpha 5 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Importin subunit alpha-5 | polymer | 563 | 63035.4 | 1 | UniProt (P52294) | Homo sapiens (human) | Karyopherin subunit alpha-1,Nucleoprotein interactor 1,NPI-1,RAG cohort protein 2,SRP1-beta |
| 2 | B (C) | GTP-binding nuclear protein Ran | polymer | 220 | 24739.4 | 1 | UniProt (P62826) | Homo sapiens (human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
| 3 | C (B) | Exportin-2 | polymer | 980 | 111382.1 | 1 | UniProt (P55060) | Homo sapiens (human) | Exp2,Cellular apoptosis susceptibility protein,Chromosome segregation 1-like protein,Importin-alpha re-exporter |
| 4 | D (C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 5 | E (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) |
Sequence modifications
A: 1 - 538 (UniProt: P52294)
C: 1 - 216 (UniProt: P62826)
B: 1 - 971 (UniProt: P55060)
| PDB | External Database | Details |
|---|---|---|
| Gly -24 | - | expression tag |
| Pro -23 | - | expression tag |
| Leu -22 | - | expression tag |
| Gly -21 | - | expression tag |
| Ser -20 | - | expression tag |
| Pro -19 | - | expression tag |
| Asn -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Arg -16 | - | expression tag |
| Val -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Ala -13 | - | expression tag |
| Ala -12 | - | expression tag |
| Thr -11 | - | expression tag |
| Met -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Tyr -8 | - | expression tag |
| Lys -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Lys -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
| Asn 73 | Ser 73 | variant |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 69 | Gln 69 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Arg -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Ile -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 199156.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 547.5 | |
| All* | Total formula weight | 199704.4 |
