11OA

Cryo-EM structure of human DNMT3A R882H octadecamer

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	DNA (cytosine-5)-methyltransferase 3A	polymer	633	72278.8	18	UniProt (Q9Y6K1)	Homo sapiens (human)	Dnmt3a,Cysteine methyltransferase DNMT3A,DNA methyltransferase HsaIIIA,DNA MTase HsaIIIA,M.HsaIIIA
2	AB, BA, BB, CA, CB... (I, C, J, D, M...)	ZINC ION	non-polymer		65.4	42	Chemie (ZN) PubChem (32051)
3	AA, FB, GB, HA, KB... (C, J, L, D, M...)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	16	Chemie (SAH) PubChem (439155)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R: 281 - 912 (UniProt: Q9Y6K1)

PDB	External Database	Details
Ser 280	-	expression tag
His 882	Arg 882	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	1301017.5
Non-Polymers*	Number of molecules	58
	Total formula weight	8897.8
All*	Total formula weight	1309915.3

*Water molecules are not included.