11NZ
Cryo-EM structure of human DNMT3A R882H decamer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | DNA (cytosine-5)-methyltransferase 3A | polymer | 633 | 72278.8 | 10 | UniProt (Q9Y6K1) Pfam (PF00855) Pfam (PF17980) Pfam (PF21255) Pfam (PF00145) | Homo sapiens (human) | Dnmt3a,Cysteine methyltransferase DNMT3A,DNA methyltransferase HsaIIIA,DNA MTase HsaIIIA,M.HsaIIIA |
| 2 | BA, IA, JA, K, L... (F, G, H, A, B...) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 10 | Chemie (SAH) PubChem (439155) | |||
| 3 | AA, CA, DA, EA, FA... (E, F, G, H, B...) | ZINC ION | non-polymer | 65.4 | 24 | Chemie (ZN) PubChem (32051) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J: 281 - 912 (UniProt: Q9Y6K1)
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | - | expression tag |
| His 882 | Arg 882 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 722787.5 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 5413.9 | |
| All* | Total formula weight | 728201.4 |
