11MR
Cryo-EM structure of CRBN in complex with HBS1L and TNG-4857 (focused refinement)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | HBS1-like protein | polymer | 208 | 22947.0 | 2 | UniProt (Q9Y450) Pfam (PF03144) Pfam (PF03143) | Homo sapiens (human) | ERFS |
| 2 | B, D (B, D) | Protein cereblon | polymer | 404 | 46378.3 | 2 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) | Homo sapiens (human) | |
| 3 | E, G (B, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, H (B, D) | N-[(3S)-2,6-dioxopiperidin-3-yl]-2-fluoro-3-[(2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}propan-2-yl)carbamamido]benzamide | non-polymer | 534.5 | 2 | Chemie (A1C9W) |
Sequence modifications
A, C: 478 - 684 (UniProt: Q9Y450)
B, D: 40 - 442 (UniProt: Q96SW2)
| PDB | External Database | Details |
|---|---|---|
| Gly 477 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 39 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 138650.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1199.8 | |
| All* | Total formula weight | 139850.4 |
