11MM

The structure of human Vacuolar Protein Sorting 34 catalytic domain bound to RD-II-81

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Phosphatidylinositol 3-kinase catalytic subunit type 3	polymer	594	68149.9	1	UniProt (Q8NEB9) Pfam (PF00613) Pfam (PF00454)	Homo sapiens (human)	PI3-kinase type 3,PI3K type 3,PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,hVps34
2	B, D (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL) PubChem (753)
3	C (A)	(8S)-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]pyrazolo[1,5-a]pyrimidine	non-polymer		294.4	1	Chemie (A1C9V)
4	E (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS) PubChem (679)
5	F (A)	water	water		18.0	21	Chemie (HOH)

Sequence modifications

A: 290 - 871 (UniProt: Q8NEB9)

PDB	External Database	Details
Met 278	-	expression tag
Gly 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag
His 284	-	expression tag
His 285	-	expression tag
His 286	-	expression tag
His 287	-	expression tag
His 288	-	expression tag
His 289	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	68149.9
Non-Polymers*	Number of molecules	4
	Total formula weight	556.7
All*	Total formula weight	68706.6

*Water molecules are not included.