11IB
2-APB bound human TRPV2, S651H/T654D/D655N
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, D, B, C) | Transient receptor potential cation channel subfamily V member 2 | polymer | 773 | 87011.8 | 4 | UniProt (Q9Y5S1) | Homo sapiens (human) | TrpV2,Osm-9-like TRP channel 2,OTRPC2,Vanilloid receptor-like protein 1,VRL-1 |
| 2 | E, H, K, N (A, D, B, C) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) PubChem (5997) | |||
| 3 | F, G, I, J, L... (A, D, B, C) | 2-aminoethyl diphenylborinate | non-polymer | 225.1 | 8 | Chemie (FZ4) PubChem (1598) |
Sequence modifications
A, D, B, C: 1 - 764 (UniProt: Q9Y5S1)
| PDB | External Database | Details |
|---|---|---|
| His 651 | Ser 651 | engineered mutation |
| Asp 654 | Thr 654 | engineered mutation |
| Asn 655 | Asp 655 | engineered mutation |
| Thr 765 | - | expression tag |
| Glu 766 | - | expression tag |
| Thr 767 | - | expression tag |
| Ser 768 | - | expression tag |
| Gln 769 | - | expression tag |
| Val 770 | - | expression tag |
| Ala 771 | - | expression tag |
| Pro 772 | - | expression tag |
| Ala 773 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 348047.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3347.4 | |
| All* | Total formula weight | 351394.7 |
