11AD
Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | polymer | 377 | 43114.7 | 1 | UniProt (P48426) Pfam (PF01504) | Homo sapiens (human) | 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha,Diphosphoinositide kinase 2-alpha,PIP5KIII,Phosphatidylinositol 5-Phosphate 4-Kinase,PI5P4Kalpha,Phosphatidylinositol 5-phosphate 4-kinase type II alpha,PI(5)P 4-kinase type II alpha,PIP4KII-alpha,PtdIns(4)P-5-kinase B isoform,PtdIns(4)P-5-kinase C isoform,PtdIns(5)P-4-kinase isoform 2-alpha |
| 2 | B, C, D (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E (A) | (7R)-8-cyclopentyl-2-(3,5-dichloro-4-hydroxyanilino)-5-methyl-7-[(pyridin-2-yl)methyl]-7,8-dihydropteridin-6(5H)-one | non-polymer | 499.4 | 1 | Chemie (A1C8V) PubChem (158009947) | |||
| 4 | F (A) | water | water | 18.0 | 204 | Chemie (HOH) |
Sequence modifications
A: 33 - 405 (UniProt: P48426)
| PDB | External Database | Details |
|---|---|---|
| Gly 29 | - | expression tag |
| Ser 30 | - | expression tag |
| His 31 | - | expression tag |
| Met 32 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43114.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 787.6 | |
| All* | Total formula weight | 43902.3 |
