10SB

PCSK9 in complex with cyclic peptide 21

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Propeptide of Proprotein convertase subtilisin/kexin type 9	polymer	122	13791.5	1	UniProt (Q8NBP7) Pfam (PF05922)	Homo sapiens (human)
2	B (B)	Proprotein convertase subtilisin/kexin type 9	polymer	308	32836.9	1	UniProt (Q8NBP7) Pfam (PF00082)	Homo sapiens (human)	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
3	C (D)	Cyclic peptide 21	polymer	9	1142.2	1		synthetic construct
4	D (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
5	E (D)	N-{[4-(2-aminoethyl)phenyl]methyl}hexan-1-amine	non-polymer		234.4	1	Chemie (A1C8P)
6	F (D)	GLYCOLIC ACID	non-polymer		76.1	1	Chemie (GOA) PubChem (757)
7	G, H, I (A, B, D)	water	water		18.0	253	Chemie (HOH)

Sequence modifications

B: 153 - 452 (UniProt: Q8NBP7)

PDB	External Database	Details
Asn 453	-	expression tag
Ser 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	47770.6
Non-Polymers*	Number of molecules	3
	Total formula weight	402.5
All*	Total formula weight	48173.1

*Water molecules are not included.