10RK
Heparin-induced trans tetrameric complex of VEGF, VEGFR2 and Neuropilin 1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, F, K (E, K, F, L) | Neuropilin-1 | polymer | 847 | 95312.6 | 4 | UniProt (P97333) Pfam (PF00431) Pfam (PF00754) Pfam (PF00629) | Mus musculus (house mouse) | A5 protein |
| 2 | C, D, H, I (A, B, G, H) | Isoform VEGF-1 of Vascular endothelial growth factor A, long form | polymer | 175 | 20787.7 | 4 | UniProt (Q00731) Pfam (PF00341) Pfam (PF14554) | Mus musculus (house mouse) | L-VEGF,Vascular permeability factor,VPF |
| 3 | E, G, J, L (C, D, I, J) | Vascular endothelial growth factor receptor 2 | polymer | 754 | 84499.0 | 4 | UniProt (P35918) Pfam (PF22854) Pfam (PF21339) Pfam (PF13927) Pfam (PF07679) Pfam (PF22971) | Mus musculus (house mouse) | VEGFR-2,Fetal liver kinase 1,FLK-1,Kinase NYK,Protein-tyrosine kinase receptor flk-1 |
| 4 | M, N (M, N) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 5 | O, P (O, P) | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose | branched | 1750.4 | 2 | In PDB GlyTouCan (G30141AL) | |||
| 6 | BA, CA, DA, EA, FA... (D, I, L, J, E...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) PubChem (24139) | |||
| 7 | AA, GA, HA, R, S... (F, L, E, K) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) PubChem (271) |
Sequence modifications
E, K, F, L: 22 - 855 (UniProt: P97333)
A, B, G, H: 27 - 190 (UniProt: Q00731)
C, D, I, J: 20 - 760 (UniProt: P35918)
| PDB | External Database | Details |
|---|---|---|
| Glu 19 | - | expression tag |
| Leu 20 | - | expression tag |
| Glu 21 | - | expression tag |
| Gly 856 | - | expression tag |
| Thr 857 | - | expression tag |
| His 858 | - | expression tag |
| His 859 | - | expression tag |
| His 860 | - | expression tag |
| His 861 | - | expression tag |
| His 862 | - | expression tag |
| His 863 | - | expression tag |
| His 864 | - | expression tag |
| His 865 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 16 | - | expression tag |
| Leu 17 | - | expression tag |
| Glu 18 | - | expression tag |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| His 21 | - | expression tag |
| His 22 | - | expression tag |
| His 23 | - | expression tag |
| His 24 | - | expression tag |
| His 25 | - | expression tag |
| His 26 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 17 | - | expression tag |
| Leu 18 | - | expression tag |
| Glu 19 | - | expression tag |
| Gly 761 | - | expression tag |
| Thr 762 | - | expression tag |
| His 763 | - | expression tag |
| His 764 | - | expression tag |
| His 765 | - | expression tag |
| His 766 | - | expression tag |
| His 767 | - | expression tag |
| His 768 | - | expression tag |
| His 769 | - | expression tag |
| His 770 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 802397.4 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 4349.7 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2975.1 | |
| All* | Total formula weight | 809722.2 |
