10RC

Human SARM1 TIR domain bound to compound 22

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	NAD(+) hydrolase SARM1	polymer	143	16205.6	2	UniProt (Q6SZW1) Pfam (PF13676)	Homo sapiens (human)	NADase SARM1,hSARM1,NADP(+) hydrolase SARM1,Sterile alpha and Armadillo repeat protein,Sterile alpha and TIR motif-containing protein 1,Sterile alpha motif domain-containing protein 2,MyD88-5,SAM domain-containing protein 2,Tir-1 homolog,HsTIR
2	C (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
3	D, E (A, B)	1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxyoxolan-2-yl]-4-{(6P)-7-{[2-(dimethylamino)ethyl]amino}-6-[6-fluoro-4-(pyrimidin-2-yl)-1H-indol-2-yl]-1-methyl-1H-imidazo[4,5-c]pyridin-2-yl}pyridin-1-ium (non-preferred name)	non-polymer		1049.9	2	Chemie (A1C9I)
4	F, G (A, B)	water	water		18.0	106	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	32411.1
Non-Polymers*	Number of molecules	3
	Total formula weight	2191.8
All*	Total formula weight	34603.0

*Water molecules are not included.