10RA

Human SARM1 TIR domain bound to compound 6

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Sterile alpha and TIR motif-containing protein 1	polymer	144	16333.7	2	UniProt (Q6SZW1) Pfam (PF13676)	Homo sapiens (human)	Sterile alpha and Armadillo repeat protein,Sterile alpha motif domain-containing protein 2,SAM domain-containing protein 2,Tir-1 homolog
2	C, D (A, B)	1-[(2R,3R,4S,5R)-5-({[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxyoxolan-2-yl]-4-[(4S,6P)-6-(5-fluoro-1H-indol-2-yl)imidazo[1,2-a]pyrazin-2-yl]pyridin-1-ium (non-preferred name)	non-polymer		871.6	2	Chemie (A1C9A)
3	E, F (A, B)	water	water		18.0	135	Chemie (HOH)

Sequence modifications

A, B: 560 - 700 (UniProt: Q6SZW1)

PDB	External Database	Details
Ser 557	-	expression tag
Asn 558	-	expression tag
Ala 559	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	32667.4
Non-Polymers*	Number of molecules	2
	Total formula weight	1743.3
All*	Total formula weight	34410.7

*Water molecules are not included.