10PF

TASK-2 at pH 8.5 with 100 uM Bupivacaine

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Potassium channel TASK2	polymer	344	38661.8	2	UniProt (Q9JK62)	Mus musculus (house mouse)	Potassium channel,subfamily K,member 5,TASK2 potassium channel
2	C (D)	Apolipoprotein A-I	polymer	211	24704.7	1	UniProt (P02647)	Homo sapiens (human)	Apo-AI,ApoA-I,Apolipoprotein A1,MSP1D1 scaffold protein
3	D, E, F, P (A, B)	POTASSIUM ION	non-polymer		39.1	4	Chemie (K) PubChem (813)
4	G (A)	Bupivacaine	non-polymer		288.4	1	Chemie (A1C7A)
5	H, I, J, K, L... (A, B)	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine	non-polymer		744.0	14	Chemie (PEE)
6	O (A)	Levobupivacaine	non-polymer		288.4	1	Chemie (OJ0) PubChem (92253)
7	X, Y (A, B)	water	water		18.0	21	Chemie (HOH)

Sequence modifications

A, B: 1 - 335 (UniProt: Q9JK62)

PDB	External Database	Details
Ser 336	-	expression tag
Asn 337	-	expression tag
Ser 338	-	expression tag
Leu 339	-	expression tag
Glu 340	-	expression tag
Val 341	-	expression tag
Leu 342	-	expression tag
Phe 343	-	expression tag
Gln 344	-	expression tag

D: 22 - 210 (UniProt: P02647)

PDB	External Database	Details
Gly 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
Asp 8	-	expression tag
Tyr 9	-	expression tag
Asp 10	-	expression tag
Ile 11	-	expression tag
Pro 12	-	expression tag
Thr 13	-	expression tag
Thr 14	-	expression tag
Glu 15	-	expression tag
Asn 16	-	expression tag
Leu 17	-	expression tag
Tyr 18	-	expression tag
Phe 19	-	expression tag
Gln 20	-	expression tag
Gly 21	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	102028.4
Non-Polymers*	Number of molecules	20
	Total formula weight	11149.7
All*	Total formula weight	113178.1

*Water molecules are not included.