10NE
Cryo-EM structure of human IL-10RA and IL-10RB in complex with tandem VHHs E07-A05
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interleukin-10 receptor subunit alpha | polymer | 227 | 25842.8 | 1 | UniProt (Q13651) | Homo sapiens (human) | IL-10 receptor subunit alpha,IL-10R subunit alpha,IL-10RA,CDw210a,Interleukin-10 receptor subunit 1,IL-10R subunit 1,IL-10R1 |
| 2 | B (B) | tandem VHHs E07-A05 | polymer | 258 | 27797.8 | 1 | synthetic construct | ||
| 3 | C (C) | Interleukin-10 receptor subunit beta | polymer | 214 | 24947.7 | 1 | UniProt (Q08334) | Homo sapiens (human) | IL-10 receptor subunit beta,IL-10R subunit beta,IL-10RB,Cytokine receptor class-II member 4,Cytokine receptor family 2 member 4,CRF2-4,Interleukin-10 receptor subunit 2,IL-10R subunit 2,IL-10R2 |
| 4 | D (H) | Fab Heavy Chain | polymer | 239 | 25684.5 | 1 | synthetic construct | ||
| 5 | E (L) | Fab Light Chain | polymer | 215 | 23258.8 | 1 | synthetic construct | ||
| 6 | F (H) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) PubChem (24139) |
Sequence modifications
A: 22 - 235 (UniProt: Q13651)
C: 20 - 220 (UniProt: Q08334)
| PDB | External Database | Details |
|---|---|---|
| Gly 236 | - | expression tag |
| Gly 237 | - | expression tag |
| Gly 238 | - | expression tag |
| Gly 239 | - | expression tag |
| Ser 240 | - | expression tag |
| His 241 | - | expression tag |
| His 242 | - | expression tag |
| His 243 | - | expression tag |
| His 244 | - | expression tag |
| His 245 | - | expression tag |
| His 246 | - | expression tag |
| His 247 | - | expression tag |
| His 248 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 221 | - | expression tag |
| Gly 222 | - | expression tag |
| Gly 223 | - | expression tag |
| Gly 224 | - | expression tag |
| Ser 225 | - | expression tag |
| His 226 | - | expression tag |
| His 227 | - | expression tag |
| His 228 | - | expression tag |
| His 229 | - | expression tag |
| His 230 | - | expression tag |
| His 231 | - | expression tag |
| His 232 | - | expression tag |
| His 233 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 127531.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 127752.8 |
