10GG

The eukaryotic translation initiation factor 2B from Homo sapiens with a L179V mutation in the delta subunit bound to methylated ISRIB

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Translation initiation factor eIF2B subunit epsilon	polymer	459	51184.8	2	UniProt (Q13144)	Homo sapiens (human)	eIF2B GDP-GTP exchange factor subunit epsilon
2	C, D (C, D)	Translation initiation factor eIF2B subunit beta	polymer	344	38395.8	2	UniProt (P49770) Pfam (PF01008)	Homo sapiens (human)	S20I15,S20III15,eIF2B GDP-GTP exchange factor subunit beta
3	E, F (G, H)	Translation initiation factor eIF2B subunit alpha	polymer	305	33754.1	2	UniProt (Q14232) Pfam (PF01008)	Homo sapiens (human)	eIF2B GDP-GTP exchange factor subunit alpha
4	G, H (I, J)	Translation initiation factor eIF2B subunit gamma	polymer	443	49304.1	2	UniProt (Q9NR50) Pfam (PF00483) Pfam (PF25084)	Homo sapiens (human)	eIF2B GDP-GTP exchange factor subunit gamma
5	I, J (E, F)	Translation initiation factor eIF2B subunit delta	polymer	356	39475.4	2	UniProt (Q9UI10) Pfam (PF01008)	Homo sapiens (human)	eIF2B GDP-GTP exchange factor subunit delta
6	K, M, O, R (C, D, E, F)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL) PubChem (312)
7	L (C)	(2S,2'S)-N,N'-[(1S,4S)-cyclohexane-1,4-diyl]bis[2-(4-chlorophenoxy)propanamide]	non-polymer		479.4	1	Chemie (A1C47)
8	N, Q (E, F)	ZINC ION	non-polymer		65.4	2	Chemie (ZN) PubChem (32051)
9	P, S (E, F)	IMIDAZOLE	non-polymer		69.1	2	Chemie (IMD)

Sequence modifications

E, F: 167 - 522 (UniProt: Q9UI10)

PDB	External Database	Details
Val 179	Leu 179	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	424228.6
Non-Polymers*	Number of molecules	9
	Total formula weight	890.2
All*	Total formula weight	425118.8

*Water molecules are not included.