10GE
The eukaryotic translation initiation factor 2B from Homo sapiens with a L179V mutation in the delta subunit, A-state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, B) | Translation initiation factor eIF2B subunit epsilon | polymer | 461 | 51385.1 | 2 | UniProt (Q13144) | Homo sapiens (human) | eIF2B GDP-GTP exchange factor subunit epsilon |
| 2 | B, F (E, F) | Translation initiation factor eIF2B subunit delta | polymer | 356 | 39475.4 | 2 | UniProt (Q9UI10) Pfam (PF01008) | Homo sapiens (human) | eIF2B GDP-GTP exchange factor subunit delta |
| 3 | C, G (G, H) | Translation initiation factor eIF2B subunit alpha | polymer | 305 | 33754.1 | 2 | UniProt (Q14232) Pfam (PF01008) | Homo sapiens (human) | eIF2B GDP-GTP exchange factor subunit alpha |
| 4 | D, H (I, J) | Translation initiation factor eIF2B subunit gamma | polymer | 443 | 49304.1 | 2 | UniProt (Q9NR50) Pfam (PF00483) Pfam (PF25084) | Homo sapiens (human) | eIF2B GDP-GTP exchange factor subunit gamma |
| 5 | I, J (C, D) | Translation initiation factor eIF2B subunit beta | polymer | 344 | 38395.8 | 2 | UniProt (P49770) Pfam (PF01008) | Homo sapiens (human) | S20I15,S20III15,eIF2B GDP-GTP exchange factor subunit beta |
| 6 | K, L (E, F) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) PubChem (32051) | |||
| 7 | M, N (C, D) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) PubChem (1061) |
Sequence modifications
E, F: 167 - 522 (UniProt: Q9UI10)
| PDB | External Database | Details |
|---|---|---|
| Val 179 | Leu 179 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 424629.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 320.8 | |
| All* | Total formula weight | 424949.9 |
