10DW

Structure of CRBN/DDB1dB-KAT2A-Compound4 ternary complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone acetyltransferase KAT2A	polymer	331	38581.3	1	UniProt (Q92830) Pfam (PF06466)	Homo sapiens (human)	General control of amino acid synthesis protein 5-like 2,Histone acetyltransferase GCN5,hGCN5,Histone glutaryltransferase KAT2A,Histone succinyltransferase KAT2A,Lysine acetyltransferase 2A,STAF97
2	B (C)	Protein cereblon	polymer	485	55144.6	1	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226)	Homo sapiens (human)
3	C (B)	DNA damage-binding protein 1	polymer	859	96193.4	1	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178)	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
4	D, E, F (A, C)	ZINC ION	non-polymer		65.4	3	Chemie (ZN) PubChem (32051)
5	G (C)	(3S)-3-[4-({6-(3-tert-butyl-2-oxoimidazolidin-1-yl)-1-[(2S)-oxan-2-yl]-1H-imidazo[4,5-c]pyridin-4-yl}amino)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione	non-polymer		600.7	1	Chemie (A1C5C)

Sequence modifications

A: 76 - 385 (UniProt: Q92830)

PDB	External Database	Details
Met 55	-	expression tag
Asp 56	-	expression tag
Trp 57	-	expression tag
Ser 58	-	expression tag
His 59	-	expression tag
Pro 60	-	expression tag
Gln 61	-	expression tag
Phe 62	-	expression tag
Glu 63	-	expression tag
Lys 64	-	expression tag
Asp 65	-	expression tag
Leu 66	-	expression tag
Gly 67	-	expression tag
Thr 68	-	expression tag
Glu 69	-	expression tag
Asn 70	-	expression tag
Leu 71	-	expression tag
Tyr 72	-	expression tag
Phe 73	-	expression tag
Gln 74	-	expression tag
Ser 75	-	expression tag

C: 1 - 442 (UniProt: Q96SW2)

PDB	External Database	Details
Met -42	-	expression tag
Asp -41	-	expression tag
Tyr -40	-	expression tag
Lys -39	-	expression tag
Asp -38	-	expression tag
Asp -37	-	expression tag
Asp -36	-	expression tag
Asp -35	-	expression tag
Lys -34	-	expression tag
Ser -33	-	expression tag
Ala -32	-	expression tag
Val -31	-	expression tag
Asp -30	-	expression tag
Glu -29	-	expression tag
Asn -28	-	expression tag
Leu -27	-	expression tag
Tyr -26	-	expression tag
Phe -25	-	expression tag
Gln -24	-	expression tag
Gly -23	-	expression tag
Gly -22	-	expression tag
Gly -21	-	expression tag
Arg -20	-	expression tag
Gly -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ala -16	-	expression tag
His -15	-	expression tag
Ile -14	-	expression tag
Val -13	-	expression tag
Met -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Ala -9	-	expression tag
Tyr -8	-	expression tag
Lys -7	-	expression tag
Pro -6	-	expression tag
Thr -5	-	expression tag
Lys -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag

B: 1 - 700 (UniProt: Q16531)

PDB	External Database	Details
Met -23	-	expression tag
Gly -22	-	expression tag
Ser -21	-	expression tag
Ser -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
Ser -13	-	expression tag
Ala -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Glu -9	-	expression tag
Asn -8	-	expression tag
Leu -7	-	expression tag
Tyr -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

B: 706 - 1140 (UniProt: Q16531)

PDB	External Database	Details
Lys 701	-	linker
Lys 702	-	linker
Lys 703	-	linker
Lys 704	-	linker
Lys 705	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	189919.3
Non-Polymers*	Number of molecules	4
	Total formula weight	796.9
All*	Total formula weight	190716.2

*Water molecules are not included.