10AI
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 N530D mutant complexed with cis-BAS-2
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein deacetylase HDAC6 | polymer | 364 | 40286.5 | 2 | UniProt (A7YT55) | Danio rerio (zebrafish) | Tubulin-lysine deacetylase HDAC6 |
| 2 | C, D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 3 | E, I (A, B) | 1-(morpholin-4-yl)-2-sulfanylethan-1-one | non-polymer | 161.2 | 2 | Chemie (A1C4P) | |||
| 4 | F, J (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) PubChem (32051) | |||
| 5 | G, H, K, L (A, B) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) PubChem (813) | |||
| 6 | M, N (A, B) | water | water | 18.0 | 384 | Chemie (HOH) |
Sequence modifications
A, B: 440 - 798 (UniProt: A7YT55)
| PDB | External Database | Details |
|---|---|---|
| Ser 435 | - | expression tag |
| Asn 436 | - | expression tag |
| Ala 437 | - | expression tag |
| Gly 438 | - | expression tag |
| Gly 439 | - | expression tag |
| Asp 530 | Asn 378 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80572.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 733.8 | |
| All* | Total formula weight | 81306.7 |
