1EBL
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THE 1.8 A CRYSTAL STRUCTURE AND ACTIVE SITE ARCHITECTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE III (FABH) FROM ESCHERICHIA COLI
Descriptor:BETA-KETOACYL-ACP SYNTHASE III, COENZYME A
Authors:Davies, C., Heath, R.J., White, S.W., Rock, C.O.
Deposit date:2000-01-24
Release date:2000-02-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli.
Structure Fold.Des., 8, 2000
1HN9
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CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III
Descriptor:BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III, PHOSPHATE ION
Authors:Qiu, X., Janson, C.A., Konstantinidis, A.K., Nwagwu, S., Silverman, C., Smith, W.W., Khandekar, S.K., Lonsdale, J., Abdel-Meguid, S.S.
Deposit date:2000-12-07
Release date:2000-12-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis.
J.Biol.Chem., 274, 1999
1HND
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CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III-COA COMPLEX
Descriptor:BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III, COENZYME A
Authors:Qiu, X., Janson, C.A., Smith, W.W., Head, M., Lonsdale, J., Konstantinidis, A.K.
Deposit date:2000-12-07
Release date:2000-12-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Refined structures of beta-ketoacyl-acyl carrier protein synthase III.
J.Mol.Biol., 307, 2001
1HNH
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CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III + DEGRADED FORM OF ACETYL-COA
Descriptor:BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III, COENZYME A
Authors:Qiu, X., Janson, C.A., Smith, W.W., Head, M., Lonsdale, J., Konstantinidis, A.K.
Deposit date:2000-12-07
Release date:2000-12-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Refined structures of beta-ketoacyl-acyl carrier protein synthase III.
J.Mol.Biol., 307, 2001
1HNJ
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CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III + MALONYL-COA
Descriptor:BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III, PHOSPHATE ION, MALONYL-COENZYME A
Authors:Qiu, X., Janson, C.A., Smith, W.W., Head, M., Lonsdale, J., Konstantinidis, A.K.
Deposit date:2000-12-07
Release date:2000-12-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Refined structures of beta-ketoacyl-acyl carrier protein synthase III.
J.Mol.Biol., 307, 2001
1HNK
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CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III, APO TETRAGONAL FORM
Descriptor:BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III
Authors:Qiu, X., Janson, C.A., Smith, W.W., Head, M., Lonsdale, J., Konstantinidis, A.K.
Deposit date:2000-12-07
Release date:2000-12-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Refined structures of beta-ketoacyl-acyl carrier protein synthase III.
J.Mol.Biol., 307, 2001
1HZP
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CRYSTAL STRUCTURE OF THE MYOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III
Descriptor:3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III, LAURIC ACID, GLYCEROL
Authors:Scarsdale, J.N., Kazanina, G., He, X., Reynolds, K.A., Wright, H.T., TB Structural Genomics Consortium (TBSGC)
Deposit date:2001-01-25
Release date:2001-06-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III
J.Biol.Chem., 276, 2001
1M1M
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X-RAY CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (MTFABH)
Descriptor:3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III
Authors:Sacchettini, J.C., Sridharan, S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2002-06-19
Release date:2002-07-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
J.Biol.Chem., 280, 2005
1MZJ
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CRYSTAL STRUCTURE OF THE PRIMING BETA-KETOSYNTHASE FROM THE R1128 POLYKETIDE BIOSYNTHETIC PATHWAY
Descriptor:Beta-ketoacylsynthase III, COENZYME A, ACETYL GROUP
Authors:Pan, H., Tsai, S.C., Meadows, E.S., Miercke, L.J.W., Keatinge-Clay, A., O'Connell, J., Khosla, C., Stroud, R.M.
Deposit date:2002-10-08
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway
Structure, 10
1MZS
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CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III WITH BOUND DICHLOROBENZYLOXY-INDOLE-CARBOXYLIC ACID INHIBITOR
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase III, PHOSPHATE ION, 1-(5-CARBOXYPENTYL)-5-(2,6-DICHLOROBENZYLOXY)-1H-INDOLE-2-CARBOXYLIC ACID
Authors:Daines, R.A., Pendrak, I., Sham, K., Van Aller, G.S., Konstantinidis, A.K., Lonsdale, J.T., Janson, C.A., Qui, X., Brandt, M., Silverman, C., Head, M.S.
Deposit date:2002-10-09
Release date:2002-11-13
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling
J.Med.Chem., 46, 2003
1U6E
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1.85 ANGSTROM CRYSTAL STRUCTURE OF THE C112A MUTANT OF MYCOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (FABH)
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase III, CHLORIDE ION
Authors:Mussayev, F., Sachedeva, S., Scarsdale, J.N., Reynolds, K.A., Wright, H.T.
Deposit date:2004-07-29
Release date:2005-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A.
J.Mol.Biol., 346, 2005
1U6S
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MYCOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III AND LAUROYL COENZYME A
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase III, DODECYL-COA
Authors:Musayev, F., Sachdeva, S., Scarsdale, J.N., Reynolds, K.A., Wright, H.T.
Deposit date:2004-07-30
Release date:2005-03-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A.
J.Mol.Biol., 346, 2005
1UB7
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THE CRYSTAL ANALYSIS OF BETA-KEROACYL-[ACYL CARRIER PROTEIN] SYNTHASE III (FABH)FROM THERMUS THERMOPHILUS.
Descriptor:3-oxoacyl-[acyl-carrier protein] synthase, GLYCEROL
Authors:Inagaki, E., Miyano, M., Tahirov, T.H., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-03-31
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Crystal Structure of Beta-Ketoacyl-[Acyl Carrier Protein] Synthase III (Fabh) from Thermus Thermophilus
To be Published
1ZOW
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CRYSTAL STRUCTURE OF S. AUREUS FABH, BETA-KETOACYL CARRIER PROTEIN SYNTHASE III
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase III
Authors:Qiu, X., Choudhry, A.E., Janson, C.A., Grooms, M., Daines, R.A., Lonsdale, J.T., Khandekar, S.S.
Deposit date:2005-05-15
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus.
Protein Sci., 14, 2005
2AHB
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X-RAY CRYSTAL STRUCTURE OF R46A,R161A MUTANT OF MYCOBACTERIUM TUBERCULOSIS FABH
Descriptor:Beta- ketoacyl-ACP synthase III
Authors:Brown, A.K., Sridharan, S., Kremer, L., Lindenberg, S., Dover, L.G., Sacchettini, J.C., Besra, G.S.
Deposit date:2005-07-27
Release date:2005-08-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Probing the Mechanism of the Mycobacterium tuberculosis {beta}-Ketoacyl-Acyl Carrier Protein Synthase III mtFabH: FACTORS INFLUENCING CATALYSIS AND SUBSTRATE SPECIFICITY
J.Biol.Chem., 280, 2005
2AJ9
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X-RAY CRYSTAL STRUCTURE OF W42A,R161A DOUBLE MUTANT OF MYCOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACP SYNTHASE III
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase III
Authors:Brown, A.K., Sridharan, S., Kremer, L., Lindenberg, S., Dover, L.G., Sacchettini, J.C., Besra, G.S.
Deposit date:2005-08-01
Release date:2005-08-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Probing the Mechanism of the Mycobacterium tuberculosis beta-Ketoacyl-Acyl Carrier Protein Synthase III mtFabH: Factors Influencing Catalysis And Substrate Specificity.
J.Biol.Chem., 280, 2005
2EBD
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CRYSTAL STRUCTURE OF 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III FROM AQUIFEX AEOLICUS VF5
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3
Authors:Kumarevel, T.S., Kuramitsu, S., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-02-08
Release date:2007-08-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase III from Aquifex aeolicus VF5
To be Published
2EFT
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METHANETHIOL-CYS 112 INHIBITION COMPLEX OF E. COLI KETOACYL SYNTHASE III (FABH) AND COENZYME A (HIGH CONCENTRATION (1.7MM) SOAK)
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3, SULFATE ION, COENZYME A, ...
Authors:Alhamadsheh, M.M., Musayev, F., Komissarov, A.A., Sachdeva, S., Wright, H.T., Scarsdale, N., Florova, G., Reynolds, K.A.
Deposit date:2007-02-24
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Alkyl-CoA Disulfides as Inhibitors and Mechanistic Probes for FabH Enzymes
Chem.Biol., 14, 2007
2GYO
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METHANETHIOL-CYS 112 INHIBITION COMPLEX OF E. COLI KETOACYL SYNTHASE III (FABH) AND COENZYME A
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3, COENZYME A, METHANETHIOL, ...
Authors:Alhamadsheh, M.M., Musayev, F., Komissarov, A.A., Sachdeva, S., Wright, H.T., Scarsdale, N., Florova, G., Reynolds, K.A.
Deposit date:2006-05-09
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Alkyl-CoA Disulfides as Inhibitors and Mechanistic Probes for FabH Enzymes.
Chem.Biol., 14, 2007
2QNX
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE MYCOBACTERIUM BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (FABH) AND 11-[(DECYLOXYCARBONYL)DITHIO]-UNDECANOIC ACID
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3, O-DECYL HYDROGEN THIOCARBONATE, 11-MERCAPTOUNDECANOIC ACID
Authors:Sachdeva, S., Musayev, F., Alhamadsheh, M., Scarsdale, J.N., Wright, H.T., Reynolds, K.A.
Deposit date:2007-07-19
Release date:2008-05-06
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15, 2008
2QNY
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE A246F MUTANT OF MYCOBACTERIUM BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (FABH) AND SS-(2-HYDROXYETHYL) O-DECYL ESTER CARBONO(DITHIOPEROXOIC) ACID
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3, DECYL FORMATE, BETA-MERCAPTOETHANOL
Authors:Sachdeva, S., Musayev, F., Alhamadsheh, M., Scarsdale, J.N., Wright, H.T., Reynolds, K.A.
Deposit date:2007-07-19
Release date:2008-05-06
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15, 2008
2QNZ
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE MYCOBACTERIUM BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (FABH) AND SS-(2-HYDROXYETHYL)-O-DECYL ESTER CARBONO(DITHIOPEROXOIC) ACID
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3, DECYL FORMATE, BETA-MERCAPTOETHANOL
Authors:Sachdeva, S., Musayev, F., Alhamadsheh, M., Scarsdale, J.N., Wright, H.T., Reynolds, K.A.
Deposit date:2007-07-19
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15, 2008
2QO0
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE A246F MUTANT OF MYCOBACTERIUM BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (FABH) AND 11-(DECYLDITHIOCARBONYLOXY)-UNDECANOIC ACID
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3, DECANE-1-THIOL
Authors:Sachdeva, S., Musayev, F., Alhamadsheh, M., Scarsdale, J.N., Wright, H.T., Reynolds, K.A.
Deposit date:2007-07-19
Release date:2008-05-06
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15, 2008
2QO1
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2.6 ANGSTROM CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN 11-(DECYLDITHIOCARBONYLOXY)-UNDECANOIC ACID AND MYCOBACTERIUM TUBERCULOSIS FABH.
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3, 11-[(MERCAPTOCARBONYL)OXY]UNDECANOIC ACID, DECANE-1-THIOL
Authors:Sachdeva, S., Musayev, F., Alhamadsheh, M., Scarsdale, J.N., Wright, H.T., Reynolds, K.A.
Deposit date:2007-07-19
Release date:2008-05-06
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15, 2008
2QX1
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MYCOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (FABH) AND DECYL-COA DISULFIDE
Descriptor:Beta-ketoacyl-ACP synthase III, COENZYME A, DECANE-1-THIOL
Authors:Sachdeva, S., Musayev, F., Alhamadsheh, M., Scarsdale, J.N., Wright, H.T., Reynolds, K.A.
Deposit date:2007-08-10
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates
Bioorg.Chem., 36, 2008
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