1W9H
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THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS.
Descriptor:CADMIUM ION, CHLORIDE ION, HYPOTHETICAL PROTEIN AF1318, ...
Authors:Parker, J.S., Roe, S.M., Barford, D.
Deposit date:2004-10-13
Release date:2005-01-13
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of a Piwi Protein Suggests Mechanisms for Sirna Recognition and Slicer Activity
Embo J., 23, 2004
1YTU
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STRUCTURAL BASIS FOR 5'-END-SPECIFIC RECOGNITION OF THE GUIDE RNA STRAND BY THE A. FULGIDUS PIWI PROTEIN
Descriptor:5'-R(P*AP*GP*AP*CP*AP*G)-3', 5'-R(P*UP*GP*UP*C)-3', MAGNESIUM ION, ...
Authors:Ma, J.B., Yuan, Y.R., Meister, G., Pei, Y., Tuschl, T., Patel, D.J.
Deposit date:2005-02-11
Release date:2005-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein.
Nature, 434, 2005
1YVU
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CRYSTAL STRUCTURE OF A. AEOLICUS ARGONAUTE
Descriptor:CALCIUM ION, hypothetical protein aq_1447
Authors:Yuan, Y.R., Pei, Y., Ma, J.B., Kuryavyi, V., Zhadina, M., Meister, G., Chen, H.Y., Dauter, Z., Tuschl, T., Patel, D.J.
Deposit date:2005-02-16
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of A. aeolicus Argonaute provides unique perspectives into the mechanism of guide strand-mediated mRNA cleavage
Mol.Cell, 19, 2005
2BGG
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THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS COMPLEXED WITH A 16NT SIRNA DUPLEX.
Descriptor:5'-R(*GP*UP*CP*GP*AP*AP*UP*UP)-3', 5'-R(*UP*UP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ...
Authors:Parker, J.S., Roe, S.M., Barford, D.
Deposit date:2004-12-22
Release date:2005-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Insights Into Mrna Recognition from a Piwi Domain-Sirna Guide Complex
Nature, 434, 2005
2F8S
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CRYSTAL STRUCTURE OF AA-AGO WITH EXTERNALLY-BOUND SIRNA
Descriptor:5'-R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*AP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3', Argonaute protein
Authors:Yuan, Y.R., Chen, H.Y., Patel, D.J.
Deposit date:2005-12-03
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA.
Structure, 14, 2006
2F8T
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CRYSTAL STRUCTURE OF AA-AGO WITH EXTERNALLY-BOUND SIRNA
Descriptor:26-MER, Argonaute protein
Authors:Yuan, Y.R., Chen, H.Y., Patel, D.J.
Deposit date:2005-12-03
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA.
Structure, 14, 2006
2NUB
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STRUCTURE OF AQUIFEX AEOLICUS ARGONUATE
Descriptor:Argonaute
Authors:Rashid, U.J., Paterok, D., Koglin, A., Gohlke, H., Piehler, J., Chen, J.C.-H.
Deposit date:2006-11-09
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Aquifex aeolicus argonaute highlights conformational flexibility of the PAZ domain as a potential regulator of RNA-induced silencing complex function.
J.Biol.Chem., 282, 2007
2W42
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THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS COMPLEXED WITH A 16NT DNA DUPLEX.
Descriptor:5'-D(*GP*TP*CP*GP*AP*AP*TP*TP)-3', 5'-D(*TP*TP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ...
Authors:Parker, J.S., Roe, S.M., Barford, D.
Deposit date:2008-11-19
Release date:2008-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Enhancement of the Seed-Target Recognition Step in RNA Silencing by a Piwi-Mid Domain Protein
Mol.Cell, 33, 2009
2YHB
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CRYSTAL STRUCTURE OF THE N. CRASSA QDE-2 AGO MID-PIWI DOMAINS
Descriptor:GLYCEROL, POST-TRANSCRIPTIONAL GENE SILENCING PROTEIN QDE-2, SULFATE ION
Authors:Boland, A., Weichenrieder, O.
Deposit date:2011-04-27
Release date:2011-06-15
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Crystal Structure of the Mid-Piwi Lobe of a Eukaryotic Argonaute Protein
Proc.Natl.Acad.Sci.USA, 108, 2011
3DLB
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CRYSTAL STRUCTURE OF THE GUIDE-STRAND-CONTAINING ARGONAUTE PROTEIN SILENCING COMPLEX
Descriptor:DNA (5'-D(*DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DA)-3'), argonaute
Authors:Wang, Y., Sheng, G., Patel, D.J.
Deposit date:2008-06-26
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the guide-strand-containing argonaute silencing complex.
Nature, 456, 2008
3DLH
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CRYSTAL STRUCTURE OF THE GUIDE-STRAND-CONTAINING ARGONAUTE PROTEIN SILENCING COMPLEX
Descriptor:ACETIC ACID, Argonaute, DNA (5'-D(DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DAP*DGP*DGP*DTP*DTP*DGP*DTP*DAP*DTP*DAP*DGP*DT)-3'), ...
Authors:Wang, Y., Sheng, G., Patel, D.J.
Deposit date:2008-06-27
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the guide-strand-containing argonaute silencing complex.
Nature, 456, 2008
3F73
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ALIGNMENT OF GUIDE-TARGET SEED DUPLEX WITHIN AN ARGONAUTE SILENCING COMPLEX
Descriptor:ARGONAUTE, DNA (5'-D(P*DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DAP*DGP*DGP*DTP*DTP*DGP*DTP*DA*DTP*DAP*DGP*DT)-3'), MAGNESIUM ION, ...
Authors:Wang, Y., Li, H., Sheng, G., Juranek, S., Tuschl, T., Patel, D.J.
Deposit date:2008-11-07
Release date:2008-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex.
Nature, 456, 2008
3HJF
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE E546 MUTANT PROTEIN COMPLEXED WITH DNA GUIDE STRAND AND 15-NT RNA TARGET STRAND
Descriptor:5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ...
Authors:Wang, Y., Li, H., Sheng, G., Patel, D.J.
Deposit date:2009-05-21
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.056 Å)
Cite:Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
3HK2
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE N478 MUTANT PROTEIN COMPLEXED WITH DNA GUIDE STRAND AND 19-NT RNA TARGET STRAND
Descriptor:5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ...
Authors:Wang, Y., Li, H., Sheng, G., Patel, D.J.
Deposit date:2009-05-22
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
3HM9
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE COMPLEXED WITH DNA GUIDE STRAND AND 19-NT RNA TARGET STRAND
Descriptor:5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ...
Authors:Wang, Y., Li, H., Sheng, G., Patel, D.J.
Deposit date:2009-05-28
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
3HO1
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE N546 MUTANT PROTEIN COMPLEXED WITH DNA GUIDE STRAND AND 12-NT RNA TARGET STRAND
Descriptor:5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*T*AP*GP*T)-3', 5'-R(P*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', MAGNESIUM ION, ...
Authors:Wang, Y., Li, H., Sheng, G., Patel, D.J.
Deposit date:2009-06-01
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
3HVR
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE COMPLEXED WITH DNA GUIDE STRAND AND 19-NT RNA TARGET STRAND WITH TWO MG2+ AT THE CLEAVAGE SITE
Descriptor:5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*TP*GP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ...
Authors:Wang, Y., Li, H., Sheng, G., Patel, D.J.
Deposit date:2009-06-16
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.211 Å)
Cite:Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
3HXM
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STRUCTURE OF AN ARGONAUTE COMPLEXED WITH GUIDE DNA AND TARGET RNA DUPLEX CONTAINING TWO MISMATCHES.
Descriptor:Argonaute, DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), MAGNESIUM ION, ...
Authors:Wang, Y., Li, H., Sheng, G., Patel, D.J.
Deposit date:2009-06-21
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
4F1N
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CRYSTAL STRUCTURE OF KLUYVEROMYCES POLYSPORUS ARGONAUTE WITH A GUIDE RNA
Descriptor:KpAGO, RNA 5'-R(P*UP*AP*AP*AP*AP*AP*AP*AP*A)-3'
Authors:Nakanishi, K., Weinberg, D.E., Bartel, D.P., Patel, D.J.
Deposit date:2012-05-07
Release date:2012-06-13
Last modified:2012-07-04
Method:X-RAY DIFFRACTION (3.187 Å)
Cite:Structure of yeast Argonaute with guide RNA.
Nature, 486, 2012
4KPY
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DNA BINDING PROTEIN AND DNA COMPLEX STRUCTURE
Descriptor:DNA (5'-D(*TP*AP*TP*AP*CP*AP*AP*CP*C)-3'), DNA (5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), ...
Authors:Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
Deposit date:2013-05-14
Release date:2014-01-29
Method:X-RAY DIFFRACTION (2.406 Å)
Cite:Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4N41
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STRUCTURE OF THERMUS THERMOPHILUS ARGONAUTE BOUND TO GUIDE DNA AND 15-MER TARGET DNA
Descriptor:5'-D(*AP*AP*CP*CP*TP*AP*CP*TP*GP*CP*CP*TP*CP*G)-3', 5'-D(P*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*T*GP*TP*AP*TP*AP*GP*T)-3', ...
Authors:Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
Deposit date:2013-10-08
Release date:2014-01-15
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (2.248 Å)
Cite:Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4N47
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STRUCTURE OF THERMUS THERMOPHILUS ARGONAUTE BOUND TO GUIDE DNA AND 12-MER TARGET DNA
Descriptor:5'-D(*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', Argonaute, ...
Authors:Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
Deposit date:2013-10-08
Release date:2014-01-15
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (2.823 Å)
Cite:Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4N76
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STRUCTURE OF THERMUS THERMOPHILUS ARGONAUTE BOUND TO GUIDE DNA AND CLEAVED TARGET DNA WITH MN2+
Descriptor:5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', Argonaute, ...
Authors:Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
Deposit date:2013-10-15
Release date:2014-01-15
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NCA
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STRUCTURE OF THERMUS THERMOPHILUS ARGONAUTE BOUND TO GUIDE DNA 19-MER AND TARGET DNA IN THE PRESENCE OF MN2+
Descriptor:5'-D(*AP*CP*AP*AP*CP*C)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', ...
Authors:Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
Deposit date:2013-10-24
Release date:2014-01-15
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (2.489 Å)
Cite:Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NCB
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STRUCTURE OF THERMUS THERMOPHILUS ARGONAUTE BOUND TO GUIDE DNA AND 19-MER TARGET DNA WITH MG2+
Descriptor:5'-D(*TP*AP*TP*AP*CP*AP*AP*CP*C)-3', 5'-D(*TP*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', ...
Authors:Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
Deposit date:2013-10-24
Release date:2014-01-15
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.189 Å)
Cite:Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
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