7YIX
| The Cryo-EM Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (ScFv) Complex. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, ... | Authors: | Yu, Y.T, Yao, D.Q, Zhang, Q, Rao, B, Xia, Y, Lu, Y, Qin, A, Ma, P.X, Cao, Y. | Deposit date: | 2022-07-18 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase. Nat Commun, 14, 2023
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7YIV
| The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Basic pH | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, ... | Authors: | Cao, Y, Qin, A, Yu, Y.T, Yao, D.Q, Zhang, Q, Rao, B, Xia, Y, Lu, Y. | Deposit date: | 2022-07-18 | Release date: | 2023-07-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase. Nat Commun, 14, 2023
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7YIW
| The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Acidic pH | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, ... | Authors: | Yu, Y.T, Yao, D.Q, Zhang, Q, Rao, B, Xia, Y, Lu, Y, Qin, A, Cao, Y. | Deposit date: | 2022-07-18 | Release date: | 2023-07-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase. Nat Commun, 14, 2023
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7QOW
| Crystal structure of Vibrio alkaline phosphatase in 1.0 M NaCl | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alkaline phosphatase, ... | Authors: | Markusson, S, Hjorleifsson, J.G, Kursula, P, Asgeirsson, B. | Deposit date: | 2021-12-29 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase. Biochemistry, 61, 2022
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7QP8
| Crystal structure of Vibrio alkaline phosphatase with bound HEPES | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Alkaline phosphatase, CHLORIDE ION, ... | Authors: | Markusson, S, Hjorleifsson, J.G, Kursula, P, Asgeirsson, B. | Deposit date: | 2022-01-03 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase. Biochemistry, 61, 2022
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7Z00
| Crystal structure of Vibrio alkaline phosphatase in 1.0 M KBr | Descriptor: | Alkaline phosphatase, BROMIDE ION, MAGNESIUM ION, ... | Authors: | Markusson, S, Hjorleifsson, J.G, Kursula, P, Asgeirsson, B. | Deposit date: | 2022-02-21 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase. Biochemistry, 61, 2022
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7YZZ
| Crystal structure of Vibrio alkaline phosphatase in 0.5 M NaCl | Descriptor: | 1,2-ETHANEDIOL, Alkaline phosphatase, CHLORIDE ION, ... | Authors: | Markusson, S, Hjorleifsson, J.G, Kursula, P, Asgeirsson, B. | Deposit date: | 2022-02-21 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase. Biochemistry, 61, 2022
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7TM9
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7KWD
| Crystal structure of Thermus thermophilus alkaline phosphatase | Descriptor: | Alkaline phosphatase, L(+)-TARTARIC ACID, MAGNESIUM ION, ... | Authors: | Gallo, G, Coelho, C, Borges, B, Negri, N, Maiello, F, Hardy, L, Wurtele, M. | Deposit date: | 2020-11-30 | Release date: | 2021-04-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Dynamic cross correlation analysis of Thermus thermophilus alkaline phosphatase and determinants of thermostability. Biochim Biophys Acta Gen Subj, 1865, 2021
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6T26
| X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine | Descriptor: | Alkaline phosphatase, CHLORIDE ION, CYCLOHEXYLAMMONIUM ION, ... | Authors: | Asgeirsson, B, Hjorleifsson, J.G, Markusson, S, Helland, R. | Deposit date: | 2019-10-07 | Release date: | 2020-10-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.265 Å) | Cite: | X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine. Biochem Biophys Rep, 24, 2020
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7JN9
| Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide QEHTGSQLRIAAYGP | Descriptor: | Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION | Authors: | Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. | Deposit date: | 2020-08-04 | Release date: | 2020-08-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein. Proc.Natl.Acad.Sci.USA, 118, 2021
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6QSQ
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6PRI
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6PSI
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5TPQ
| E. coli alkaline phosphatase D101A, D153A, R166S, E322A, K328A mutant | Descriptor: | Alkaline phosphatase, PHOSPHATE ION, ZINC ION | Authors: | Sunden, F, AlSadhan, I, Lyubimov, A.Y, Doukov, T, Swan, J, Herschlag, D. | Deposit date: | 2016-10-20 | Release date: | 2017-11-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution. J. Biol. Chem., 292, 2017
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5JTL
| The structure of chaperone SecB in complex with unstructured proPhoA | Descriptor: | Alkaline phosphatase, Protein-export protein SecB | Authors: | Huang, C, Saio, T, Rossi, P, Kalodimos, C.G. | Deposit date: | 2016-05-09 | Release date: | 2016-08-24 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis for the antifolding activity of a molecular chaperone. Nature, 537, 2016
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5JTP
| The structure of chaperone SecB in complex with unstructured proPhoA binding site e | Descriptor: | Alkaline phosphatase, Protein-export protein SecB | Authors: | Huang, C, Saio, T, Rossi, P, Kalodimos, C.G. | Deposit date: | 2016-05-09 | Release date: | 2016-08-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural basis for the antifolding activity of a molecular chaperone. Nature, 537, 2016
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5C66
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4YR1
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2MLZ
| NMR structure of E. coli Trigger Factor in complex with unfolded PhoA365-471 | Descriptor: | Alkaline phosphatase, Trigger factor | Authors: | Saio, T, Guan, X, Rossi, P, Economou, A, Kalodimos, C.G. | Deposit date: | 2014-03-05 | Release date: | 2014-05-21 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis for protein antiaggregation activity of the trigger factor chaperone. Science, 344, 2014
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3WBH
| Structural characteristics of alkaline phosphatase from a moderately halophilic bacteria Halomonas sp.593 | Descriptor: | Alkaline phosphatase, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Arai, S, Yonezawa, Y, Ishibashi, M, Matsumoto, F, Tamada, T, Tokunaga, H, Tokunaga, M, Kuroki, R. | Deposit date: | 2013-05-17 | Release date: | 2014-03-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural characteristics of alkaline phosphatase from the moderately halophilic bacterium Halomonas sp. 593. Acta Crystallogr.,Sect.D, 70, 2014
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4KJD
| RatIntestinal AP expressed in E. coli | Descriptor: | GLYCEROL, Intestinal-type alkaline phosphatase 1, MAGNESIUM ION | Authors: | Ghosh, K, Anumula, R.K, Laksmaiah, B.K. | Deposit date: | 2013-05-03 | Release date: | 2013-10-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Crystal structure of rat intestinal alkaline phosphatase - Role of crown domain in mammalian alkaline phosphatases. J.Struct.Biol., 184, 2013
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4KJG
| Structure of Rat Intestinal Alkaline Phosphatase expressed in insect cell | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ghosh, K, Anumula, R.K, Laksmaiah, B.K. | Deposit date: | 2013-05-03 | Release date: | 2013-10-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Crystal structure of rat intestinal alkaline phosphatase - Role of crown domain in mammalian alkaline phosphatases. J.Struct.Biol., 184, 2013
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4KM4
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3TG0
| E. coli alkaline phosphatase with bound inorganic phosphate | Descriptor: | Alkaline phosphatase, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Bobyr, E, Lassila, J.K, Wiersma-Koch, H.I, Fenn, T.D, Lee, J.J, Nikolic-Hughes, I, Hodgson, K.O, Rees, D.C, Hedman, B, Herschlag, D. | Deposit date: | 2011-08-16 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | High-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallography. J.Mol.Biol., 415, 2012
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